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Box plots illustrating (a) the number of CSF-specific oligoclonal bands (OCB) of OCB positive persons with MS and CIS, (b) intrathecal produced amount of IgG of persons with MS and CIS with detectable IgG-synthesis, according to Reiber’s diagram, and (c) KFLC index of all persons with MS and CIS with KFLC index >6.1. Panel (d) shows OCB count cross across different clinical presentation types. Boxes represent interquartile range with horizontal line within the box representing the median. Lower and upper whiskers represent min. and max. values. MS, multiple sclerosis; CIS, clinically isolated syndrome; OCB, oligoclonal bands; CSF, cerebrospinal fluid; IgG, immunoglobulin G; KFLC, <t>kappa</t> free light chains.
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Box plots illustrating (a) the number of CSF-specific oligoclonal bands (OCB) of OCB positive persons with MS and CIS, (b) intrathecal produced amount of IgG of persons with MS and CIS with detectable IgG-synthesis, according to Reiber’s diagram, and (c) KFLC index of all persons with MS and CIS with KFLC index >6.1. Panel (d) shows OCB count cross across different clinical presentation types. Boxes represent interquartile range with horizontal line within the box representing the median. Lower and upper whiskers represent min. and max. values. MS, multiple sclerosis; CIS, clinically isolated syndrome; OCB, oligoclonal bands; CSF, cerebrospinal fluid; IgG, immunoglobulin G; KFLC, kappa free light chains.

Journal: Frontiers in Neurology

Article Title: Assessing the value of oligoclonal band count in multiple sclerosis: insights from a large cohort analysis

doi: 10.3389/fneur.2026.1719470

Figure Lengend Snippet: Box plots illustrating (a) the number of CSF-specific oligoclonal bands (OCB) of OCB positive persons with MS and CIS, (b) intrathecal produced amount of IgG of persons with MS and CIS with detectable IgG-synthesis, according to Reiber’s diagram, and (c) KFLC index of all persons with MS and CIS with KFLC index >6.1. Panel (d) shows OCB count cross across different clinical presentation types. Boxes represent interquartile range with horizontal line within the box representing the median. Lower and upper whiskers represent min. and max. values. MS, multiple sclerosis; CIS, clinically isolated syndrome; OCB, oligoclonal bands; CSF, cerebrospinal fluid; IgG, immunoglobulin G; KFLC, kappa free light chains.

Article Snippet: Serum and CSF concentrations of KFLC were measured using nephelometry with the N Latex FLC kappa kit (Siemens Healthcare Diagnostics Products GmbH), following the manufacturer’s instructions on an Atellica Neph 630 System (Siemens Healthcare Diagnostics Products GmbH).

Techniques: Produced, Isolation

Receiver operating characteristic (ROC) curves for the differentiation of MS and CIS ( n = 269). The plot illustrates the diagnostic accuracy of OCB count, KFLC index, intrathecal IgG synthesis according to Reiber, and the combination of OCB count and KFLC index. The area under the curve (AUC) with corresponding 95% confidence interval (CI) for each methodology is indicated in the legend. The distinct inflection point in the intrathecal IgG curve reflects the high proportion of individuals with a calculated IgG synthesis of 0.0 mg/L, where the methodology reaches its limit of continuous discrimination. MS, multiple sclerosis; CIS, clinically isolated syndrome; OCB, oligoclonal bands; KFLC, kappa free light chain; IgG, immunoglobulin G.

Journal: Frontiers in Neurology

Article Title: Assessing the value of oligoclonal band count in multiple sclerosis: insights from a large cohort analysis

doi: 10.3389/fneur.2026.1719470

Figure Lengend Snippet: Receiver operating characteristic (ROC) curves for the differentiation of MS and CIS ( n = 269). The plot illustrates the diagnostic accuracy of OCB count, KFLC index, intrathecal IgG synthesis according to Reiber, and the combination of OCB count and KFLC index. The area under the curve (AUC) with corresponding 95% confidence interval (CI) for each methodology is indicated in the legend. The distinct inflection point in the intrathecal IgG curve reflects the high proportion of individuals with a calculated IgG synthesis of 0.0 mg/L, where the methodology reaches its limit of continuous discrimination. MS, multiple sclerosis; CIS, clinically isolated syndrome; OCB, oligoclonal bands; KFLC, kappa free light chain; IgG, immunoglobulin G.

Article Snippet: Serum and CSF concentrations of KFLC were measured using nephelometry with the N Latex FLC kappa kit (Siemens Healthcare Diagnostics Products GmbH), following the manufacturer’s instructions on an Atellica Neph 630 System (Siemens Healthcare Diagnostics Products GmbH).

Techniques: Diagnostic Assay, Isolation

Scatter plots showing the positive correlations between the number of oligoclonal bands (OCB) in CSF with (a) intrathecal IgG levels (rho = 0.6963, p < 0.0001) and (b) KFLC index (rho = 0.7099, p < 0.0001). MS, multiple sclerosis; OCB, oligoclonal bands; CSF, cerebrospinal fluid; KFLC, kappa free light chains; EDSS, IgG, immunoglobulin G.

Journal: Frontiers in Neurology

Article Title: Assessing the value of oligoclonal band count in multiple sclerosis: insights from a large cohort analysis

doi: 10.3389/fneur.2026.1719470

Figure Lengend Snippet: Scatter plots showing the positive correlations between the number of oligoclonal bands (OCB) in CSF with (a) intrathecal IgG levels (rho = 0.6963, p < 0.0001) and (b) KFLC index (rho = 0.7099, p < 0.0001). MS, multiple sclerosis; OCB, oligoclonal bands; CSF, cerebrospinal fluid; KFLC, kappa free light chains; EDSS, IgG, immunoglobulin G.

Article Snippet: Serum and CSF concentrations of KFLC were measured using nephelometry with the N Latex FLC kappa kit (Siemens Healthcare Diagnostics Products GmbH), following the manufacturer’s instructions on an Atellica Neph 630 System (Siemens Healthcare Diagnostics Products GmbH).

Techniques: